GSK shuffles top management
GlaxoSmithKline plc (LSE:GSK; NYSE:GSK) reshuffled its executive management as it prepares to integrate the vaccines business it is acquiring from Novartis AG (NYSE:NVS; SIX:NOVN) in an asset-swapping deal announced in April. The shake-up was announced along with third-quarter earnings (see BioCentury, April 28).
Biogen falls on Tecfidera miss
Biogen Idec Inc. (NASDAQ:BIIB) fell $17.70 (5%) to $309.07 on Wednesday after reporting that Tecfidera dimethyl fumarate revenues were $787 million in 3Q14, short of the $800 million consensus estimate.
GSK mulling ViiV IPO
GlaxoSmithKline plc (LSE:GSK; NYSE:GSK) said it is considering an IPO for ViiV Healthcare Ltd., the HIV joint venture it formed with Pfizer Inc. (NYSE:PFE) in 2009. On GSK's third quarter earnings call, CEO Andrew Witty said the company was considering a "partial IPO or IPO of a minority stake," likely no sooner than 2016.
Bavarian Nordic gains on J&J Ebola deal
Bavarian Nordic A/S (CSE:BAVA) gained DKK36.50 (24%) to DKK186.50 after the Crucell Holland B.V. unit of Johnson & Johnson (NYSE:JNJ) paid $25 million up front to license exclusive, worldwide rights to Ebola vaccine MVA-BN Filo. Bavarian Nordic is eligible for $20 million in milestones, plus royalties on commercial sales outside Africa. Concurrently, J&J Development Corp. will acquire a 6.4% stake in Bavarian Nordic for DKK251 million ($43 million) via a private placement of new shares.
NICE draft recommends Xarelto in ACS patients
The U.K.'s NICE issued draft guidance recommending use of Xarelto rivaroxaban from Bayer AG (Xetra:BAYN) in combination with aspirin plus clopidogrel or aspirin alone to prevent blood clots in patients who have acute coronary syndrome (ACS) with elevated cardiac biomarkers.
WuXi licenses Foundation's cancer genomics test
Foundation Medicine Inc. (NASDAQ:FMI) has licensed the laboratory component of its FoundationOne genomic profiling test for solid tumors to WuXi PharmaTech Inc. (NYSE:WX). Oncologists use the laboratory-developed test to identify patients' somatically altered genes and match them with targeted therapies and clinical trials. WuXi's Genome Center in Shanghai, the only CLIA-certified lab in China, will offer the test to companies conducting clinical trials in the country. The companies did not disclose financial terms.
Regulus doubles on interim HCV data
Regulus Therapeutics Inc. (NASDAQ:RGLS) surged $6.98 (103.1%) to $13.75 on Wednesday after announcing interim results from a Phase I trial in which a single 2 mg/kg injection of antisense therapy RG-101 led to significant and sustained viral reductions in HCV-infected patients.
NIH begins second trial of NewLink's Ebola vaccine
NewLink Genetics Corp. (NASDAQ:NLNK) gained $4.01 (12%) to $38.51 on Wednesday after NIH's National Institute of Allergy and Infectious Diseases (NIAID) said it had begun the second Phase I trial of its investigational Ebola vaccine VSV-EBOV (BPSC1001).
Forendo closes EUR 12M series A
Forendo Pharma Oy (Turku, Finland) closed a EUR 12 million ($15.3 million) series A round led by new investors Novartis Venture Fund and MS Ventures. Existing investors including Karolinska Development AB; Novo Seeds; and Finnvera also participated.
Proteon raises $61.1M in IPO
Proteon Therapeutics Inc. (NASDAQ:PRTO) closed up $0.03 to $10.03 in its first day of trading Wednesday after raising $61.1 million by selling 6.1 million shares at $10 in an IPO on NASDAQ. The price valued Proteon at $149.9 million. Stifel; JMP Securities; Baird; and Oppenheimer are underwriters.
Molecular Partners postpones big Swiss IPO
Ophthalmic and cancer company Molecular Partners AG (Schlieren, Switzerland) postponed plans for a big IPO on the SIX Swiss Exchange, citing "adverse market conditions." The company had begun bookbuilding on Oct. 8 and was scheduled to begin trading today. Last month, it filed to raise CHF125 million ($133.1 million) in the offering.
DBV Technologies launches ADSs
American Depository Receipts for DBV Technologies S.A. (NASDAQ:DBVT; Euronext:DBV) added $1.26 to $22.90 on NASDAQ Wednesday after the allergy company sold 4.3 million ADSs at $21.64 each in a follow-on that, combined with a private placement outside the U.S. and Canada, will raise about $115.8 million.